Shenyang Institute of Automation and others have made progress in the fields of biomanufacturing and nanomechanical analysis_Zhongke Frontier (Xiamen) Science and Technology Research Institute

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Shenyang Institute of Automation and others have made progress in the fields of biomanufacturing and nanomechanical analysis

Time：2024-03-15 06:56:11

Recently, the Shenyang Institute of Automation of the Chinese Academy of Sciences cooperated with China Medical University to explore the relationship between the results of nanomechanical analysis and the malignancy of gastric cancer and peritoneal metastasis by constructing an in vitro bionic peritoneum. The relevant research results are titled Nanomechanical Analysis of Living Small Extracellular Vehicles to Identify Gastric Cancer Cell Malignancy Based on a Biometric Peritoneum and published in ACS NANO.

Gastric cancer is one of the common malignant tumors in the digestive tract. The terminal stage of gastric cancer is characterized by peritoneal metastasis, which is the main cause of patient death. Therefore, effective in vitro peritoneal model research is beneficial for exploring the potential mechanisms of peritoneal metastasis in gastric cancer cells. This study constructed a biomimetic peritoneal tissue. This organization is similar to the real peritoneum in terms of internal microstructure, components, and main functions, and can reproduce the process of peritoneal metastasis in vitro.

Based on biomimetic peritoneal tissue, the team analyzed the role of small extracellular vesicles in peritoneal metastasis. Through nanomechanical analysis of small extracellular vesicles, it was found that their Young's modulus can be used to distinguish between malignant clinical samples (ascites) and non malignant clinical samples (peritoneal lavage fluid). In addition, experiments have confirmed that small extracellular vesicles obtained in the patient's ascites can stimulate mesothelial mesenchymal transition, thereby promoting peritoneal metastasis. Research has shown that nanomechanical analysis of small extracellular vesicles is expected to provide potential technical means for determining the malignancy of gastric cancer.

The research work was supported by the National Key Research and Development Program, the National Natural Science Foundation of China, and the Chinese Academy of Sciences Youth Team Program for Stable Support in Basic Research.

Biomimetic peritoneal construction and nanomechanical analysis schematic diagram