Chongqing Research Institute and others have made progress in the construction and application of new solid-state nanochannel devices_Zhongke Frontier (Xiamen) Science and Technology Research Institute

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Chongqing Research Institute and others have made progress in the construction and application of new solid-state nanochannel devices

Time：2024-04-29 08:14:30

In recent years, the development of nanochannel single-molecule analysis has been rapid. However, the low reproducibility and signal-to-noise ratio of solid-state nanopore structures, as well as the low stability of biological nanopore support systems, limit the large-scale application of nanopore technology.

The Precision Medical Center of the Chinese Academy of Sciences Chongqing Institute of Green and Intelligent Technology has cooperated with Huazhong University of Science and Technology to build a new organic/inorganic composite nano channel for the identification of single amino acids and chirality.

The chiral aromatic amide molecules designed in this study can spontaneously fold into helical channels in the solution phase. Meanwhile, amino acid like helical molecules as nanochannels have good ion transport selectivity and stability, comparable to the performance of natural protein channels. This study combines the physical and chemical stability of inorganic silicon nitride materials, as well as the designability and tunable inner cavity of organic spiral chiral molecules, to construct a novel lipid free small-sized protein like composite chiral nanochannel, forming a stable analysis platform with a sturdy exterior and high reproducibility of internal surface size and surface properties.

The composite channel constructed in this work exhibits good ion transport performance in different ion solutions, and can identify different single amino acids and amino acid chiral enantiomers. It demonstrates the potential of sub nanoscale organic/inorganic hybrid ion channels for peptide and protein sensing at the single amino acid level, laying the foundation for the sequencing application of composite solid-state nanochannels.

The relevant research results are titled Construction and Applications of Hybrid Nanochannels with Helical Folders and Solid State Nanopores and published in the Chemical Engineering Journal. The research work was supported by the "Light of the West" talent training plan of the Chinese Academy of Sciences.

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